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A molecules effect depends not only on its intrinsic biology but on where it goes, how much of it reaches the target tissue, how long it persists, and what else it interacts with along the way

Moreover, GLP-1R agonists, including liraglutide, have been shown to inhibit proliferation, cell cycle progression, and/or migration in lung [13], pancreatic [31, 32], prostate [26], endometrial [15, 23], and murine colon cancer cells [38], although they were reported to promote the proliferation of breast cancer cells [14]

Their effects on glucose regulation, weight, and overall metabolic health may indirectly influence how patients perceive their energy levels

doi: 10.1038/s41419-022-04708-w 90 LiuMKongXYYaoYWangXAYangWWuHet al

Financial support and sponsorship This work was supported by funds from the following institutions: Institut National de la Sant et de la Recherche Mdicale - INSERM, Fondation pour la Recherche Mdicale, the Conseil Rgional dAquitaine, Fondation ARC pour la Recherche sur le Cancer, Ligue Contre le Cancer - Gironde, SIRIC-BRIO, Institut Europen de Chimie et Biologie, and University of Bordeaux

We also detected the activation of astrocytes around the hematoma, the expression of GFAP without significant difference (Supplementary Figure 2)